PRODUCT DESCRIPTION:

Pancuronium Bromide Injection is a long-acting non-depolarizing neuromuscular blocking agent used to induce skeletal muscle relaxation during surgery or mechanical ventilation.

It works by competitively blocking acetylcholine at the neuromuscular junction, resulting in muscle paralysis required for endotracheal intubation and surgical procedures.

This product is widely used in anesthesia practice and intensive care units to facilitate controlled ventilation and prevent spontaneous respiratory effort during critical interventions.

Formulation & Presentation:

• Dosage Form: Sterile Injectable
• Presentation: Clear Sterile Solution in Clear/Amber Glass Vial/ Ampoule (customizable as per market demand)
• Available Strengths:
  • Pancuronium Bromide Injection: 1 MG/ ML
• Route of Administration: Intravenous (IV) Only. To be used after appropriate reconstitution or as per clinical indication and recommendation. Reconstituted as per protocol for injection in country of use. To be administered under strict supervision of a qualified doctor or as per physician’s discretion or decision only.

Therapeutic Indications:

• Adjunct to general anesthesia for skeletal muscle relaxation during surgery
• Facilitation of endotracheal intubation
• Maintenance of controlled ventilation in ICU patients
• Use during electroconvulsive therapy (ECT) procedures

Side Effects:

• COMMON:
  • Transient increase in heart rate (tachycardia)
  • Elevated blood pressure
  • Hypersalivation
  • Prolonged muscle paralysis
• SERIOUS (RARE):
  • Severe hypotension or hypertension
  • Anaphylactic reaction
  • Respiratory depression or apnea
  • Bronchospasm
  • Cardiac arrhythmias
• PRECAUTIONS:
  • Should only be administered by experienced personnel with facilities for intubation and respiratory support
  • Use with caution in patients with hepatic or renal impairment
  • Avoid use in patients with neuromuscular diseases (e.g., myasthenia gravis)
  • Continuous ECG, pulse oximetry, and neuromuscular function monitoring recommended
  • Reversal agents (e.g., neostigmine with atropine) should be readily available