PRODUCT DESCRIPTION:

Amifostine is a cytoprotective adjuvant used to reduce the cumulative toxicity of chemotherapy and radiation therapy.

It is particularly effective in protecting normal tissues from the harmful effects of alkylating agents and platinum-based chemotherapies, without reducing the anti-tumor efficacy.

The Amifostine Injection 500 MG Pre-Filled Syringe is a ready-to-administer, sterile solution that offers accuracy, speed, and sterility—making it ideal for use in oncology centers and high-dependency units. Its pre-filled syringe format reduces preparation time and minimizes the risk of dosing errors.

Formulation & Presentation:

• Dosage Form: Injectable Solution – Pre Filled Syringe
• Presentation: Pre-Filled Syringe (customizable as per market demand)
• Available Strengths: 500 MG of Amifostine Per Syringe
• Route of Administration: Intravenous Infusion Slow IV or as per clinical indication and severity (As per physician’s discretion or decision)

Therapeutic Indications:

• Protection against cumulative renal toxicity associated with cisplatin in patients undergoing chemotherapy
• Reduction of xerostomia (dry mouth) in patients receiving postoperative radiation therapy for head and neck cancer
• Used selectively for myeloprotection and neuroprotection in oncology

Side Effects:

• COMMON:
  • Nausea and vomiting
  • Hypotension (transient)
  • Flushing or warm sensation
  • Dizziness or fatigue
• SERIOUS (RARE):
  • Severe hypotension requiring intervention
  • Allergic reactions (rash, bronchospasm, anaphylaxis)
  • Seizures
  • Loss of consciousness (extremely rare)
• PRECAUTIONS:
  • Administer under strict medical supervision in a controlled hospital setting
  • Pre-hydration and blood pressure monitoring are essential
  • Contraindicated in patients with unstable angina or recent cerebrovascular accident
  • Antiemetic premedication recommended to prevent nausea/vomiting
  • Not recommended during pregnancy or lactation unless absolutely necessary